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BioInspired Awards Two Cross-Institutional Project Grants

Syracuse University’s BioInspired Institute has awarded a new round of intramural grants to two interdisciplinary, cross-institutional research projects.

One project looks at how polar fungi physically adapt to survive in extreme climate environments. Its researchers are working to determine how the fungi copy and transfer DNA code at the genetic, molecular, biophysical, cellular and organismal levels.

The second project examines how shape-memory polymers react to both synthetic and biological stimuli and how various treatments affect the materials’ makeup and characteristics. The research team is studying the processes organisms use to successfully adjust their molecular structure to overcome energetic barriers. Continue Reading

‘Fishing’ for Biomarkers

While a popular hobby for many, fishing is also a pastime full of uncertainty. Each time you have something on the line, you can never be completely sure what type of fish you’ve hooked until you pull it out of the water. In a similar way, scientists “fishing” for biomarkers—molecules whose health care applications include signaling for the presence of cancer—in such biofluids as blood can also encounter unpredictability. Finding a specific protein biomarker in a pool of thousands is like trying to catch a particular fish species in the vast ocean.

Luckily, a team of researchers from the College of Arts and Sciences (A&S), SUNY Upstate Medical University, Ichor Therapeutics and Clarkson University have devised a tiny, nano-sized sensor capable of detecting protein biomarkers in a sample at single-molecule precision. Fittingly coined as “hook and bait,” a tiny protein binder fuses to a small hole created in the membrane of a cell—known as a nanopore—which allows ionic solution to flow through it. When the sensor recognizes a targeted molecule, the ionic flow changes. This change in flow serves as the signal from the sensor that the biomarker has been found.

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